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Corticobasal degeneration (CBD) is a progressive neurological disorder. It is associated with atrophy of the cerebral cortex and the basal ganglia. Corticobasal degeneration (CBD) commonly occurs in patients age 45 to 70, with women affected more frequently than men. The combined loss of brain tissue in all these areas causes the symptoms. The first symptoms frequently involve stiff, shaky, slow and clumsy movements in either the arms or legs. Other early symptoms may involve problem walking and balancing , short-term memory problems, problem controlling the muscles of the face and mouth.

Progressive problem speaking or articulating as well as problem comprehending language. Some of the symptoms, like poor coordination and rigidity, are alike to those found in Parkinson's disease. Symptoms involve parkinsonism like poor coordination, akinesia (an absence of movements), rigidity (a resistance to imposed movement), and disequilibrium (impaired balance); and limb dystonia. Corticobasal degeneration commonly progresses slowly over the course of 6 to 8 years. Death is commonly caused by pneumonia or other difficulties of severe debility like sepsis or pulmonary embolism.

Corticobasal degeneration is unusual. There is no treatment accessible to decelerate the class of corticobasal degeneration. Antiparkinsonian drugs do not develop any substantial or continuous advance. Clonazepam may assist the myoclonus. Occupational, physical, and address therapy may assist in managing impairment. Physical therapy may assist to preserve a scope of movement in tight joints, in twist helping to forbid pain and suffer mobility. Occupational therapy may be useful in providing and developing useful adaptive equipment. Speech therapy may better articulation and book. Clonazepam may assist the myoclonus.

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