Health and Medical News

Lung Transplants Not Dangerous For Children With Cystic Fibrosis, After All - Experts Say Recent Stu

Health and Medical News - Transplants & Organ Donations
Tuesday, 01 April 2008
Responding to a study published in the New England Journal of Medicine, which concluded that lung transplants were damaging for children with cystic fibrosis, articles published in the newest issue of Pediatric Transplantation refute the conclusions and argue that the greatly influential research was severely flawed. According to 2 rebuttals published in the acclaimed journal, the conclusions of the study on post-transplant survival rates led by Theodore G. Liou, M.D., of the University of Utah, Salt Lake City, were earnestly flawed by misinterpreted statistics that made a strong bias against transplantation. "Dr. Liou, et al. are accomplished statisticians and admirable academicians," says Thomas M. Egan, M.D., of the University of North Carolina at Chapel Hill in his systematic rejection of the study. "But sometimes statistics do not tell the truth." Using covariates obtained up to 3 years before actual transplantation and when predicted survival was great, the calculated hazard ratios Liou's study put forth were based on outdated info that did not reflect true benefit on a patient-by-patient basis at the time of actual transplant, contend Egan and Stuart C. Sweet, M.D. of Washington University, St. Louis. Liou's study also conflicts with findings from other sources, in which survival rates for pediatric CF lung transplant recipients were substantially higher. Furthermore, recent changes in the U.S. transplant allocation policy, which appears to be successfully directing organs to those more at risk of dying on the waiting list and with higher survival benefit, have rendered the findings of Liou's work irrelevant. "Because uncritical acceptance of the study results by third party payers, referring physicians, and lung transplant centers could place children with cystic fibrosis who would likely benefit from lung transplants at risk, we appreciate Pediatric Transplantation providing this opportunity to speedily publish an independent critique of the article," says Dr. Sweet. Pediatric Transplantation is the only journal dedicated to transplantation in infants, children and adolescents. The journal aims to advance science and practice of transplantation in children worldwide, by providing a forum that highlights the most recent advances in clinical and basic science related to this field. For more info, please visit http://www.blackwell-synergy.com/loi/ptr. Wiley-Blackwell was formed in February 2007 as a result of the acquisition of Blackwell Publishing Ltd. by John Wiley & Sons, Inc., and its merger with Wiley's Scientific, Technical, and Medical business. Together, the companies have made a global publishing business with deep strength in every major academic and professional field. Wiley-Blackwell publishes approximately 1,400 scholarly peer-reviewed journals and an extensive collection of books with global appeal. For more info on Wiley-Blackwell, please visit http://www.blackwellpublishing.com or http://interscience.wiley.com.

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